The new 14-storey tower which is nearing completion at Nepean Hospital has generated more than a million hours of onsite construction work.
It is part of a $1 billion staged upgrade of the facility.
Penrith MP Stuart Ayres said that the tower had become the tallest landmark in the Penrith catchment area.
"As one of the biggest hospital infrastructure projects in the state, the Nepean redevelopment is a great source of employment for people from across western Sydney," he said.
Since construction started, more than 3650 workers have been engaged in the project.
In recent weeks the construction crane was taken away and the scaffolding removed. Nepean Hospital staff have also started to plan their moves.
"Work is now being focused on the interior fit-out of the tower including the installation of major medical equipment and new technology systems to ensure the communities in Penrith and the Blue Mountains have access to world-class health care now, and into the future," Mr Ayres said.
The tower is on track to open in the first half of 2022. It will deliver an expanded emergency department, 18 birthing suites, a neo-natal intensive care unit, 16 digital operating theatres, more than 200 additional beds and a roof-top helipad.
Designs for the second stage of the hospital building is well under way and construction is scheduled to start following the opening of the tower.
Stage two will include a new intensive care unit, in-centre renal dialysis unit, medical imaging and nuclear medicine services, cardiology services, more beds, community health services and a front of house for the hospital.
A community open day, where folk will be able to preview the new tower, is being planned for early next year.